The Mar Thoma Yuvajana Sakhyam was organized with a view that all the young people in the Church should accept Jesus Christ as their saviour and Lord, and bear witness to His saving power. It was organized in 1933 by a resolution of the Sabha Prathinidhi Mandalam. The first president of the Sakhyam was Rev.V P Mammen and the Vice- Presidents were Rev. K E Oommen and Rev. C M John (later Juhanon Mar Thoma Metropolitan) and the first Secretary was Mr. V E Thomas (later Rev. V E Thomas, Singapore). Branches of the Sakhyam were set up in the Parishes with a four-fold programme of worship, study, witness and service. Mr. M M Thomas (later Dr. M M Thomas) was appointed as Organising Secretary in 1945 and he was the full time worker of the Sakhyam. Under his dynamic leadership, the Sakhyam struck deep roots and spread its branches far and wide.

Most of the Parishes both inside and outside Kerala have branches of the Sakhyam. A group of such branches form a center. There are a number of such Centres under each Diocese. The Constitution of the Sakhyam prescribes that the President should be a Bishop of the Church.